Pyr Science Questions


https://play.pyr.ai/#!middleauth+https://global.daf-apis.com/nglstate/api/v1/6328861865279488

what even is this cell? I’ve seen less twists, turns and loop de loops in Agatha Christie novels!

No, srly what type of neuron is this cell? It reminds me of the ‘bouquet’ cells in FW fly brain that would circle around break off into many sub branches and end up in the ‘bouquet of flowers’ kind of thing, but this is no fly brain.

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This may have been answered in one of the town halls/zoom calls but how come is the dataset we’re currently working in like a smaller dataset inside a bigger dataset? Is the larger one going to be available later on or is it blocked off for some other reason?

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Anyone can feel free to finish those two “demos” from Challenge 1 if you’d like!

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I’m not sure on the reason for the two differently sized bounding boxes here, but we are currently working in the full dataset.

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ah, interesting part is 3D ends in smaller bounding box, but 2D (scrolling) does go on the left/right/front/ back sides (at least for a bit further out) but ends on the up/down sides.


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to the best of GMs/Lab knowledge will we have enough of the Hippocampus in the 1mm dataset to get an MF whole? (axon, CB and dendrites)?

B/c I think what we are tracing in this dataset are the axons only.

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Could I ask what 1mm dataset you are referring to? Right now I think the CA3 dataset is the only one we have in this area of the brain.

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if memory serves me right I remember watching the pyr release vid. and amy mentioning that there’s a new dataset to be released in the next few months that is going to be 1mm x1mm x1mm and will be the largest dataset to be traced to date. I just don’t remember if it’ll be in the hippocampus or the new mouse retina.

from what i remember it think she did say that that the orginal NEO dataset was 1mm x 1mm but that they had not managed to prepare it.

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We don’t currently have another hippocampal dataset in the works at the moment as far as I’m aware.

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I’m curious: Us tracing all the MFs and/or other cell types that go through the Dataset, are we only mapping pre/post synaptic connections to Pyramid cells or is it also part of the research to identify different cell sub-types and/or cell types previously unknown to science like we did in EW/FW and/or doing now in BANC?

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Good question!

One of main goals is to observe the frequency and types of connections that are being made to the Pyramidal cells. This is why the tasks we are doing in CA3 are identifying/reconstructing Mossy Fibers and other branches that have pre/post synaptic connections to the Pyramidal cells.

For Mossy Fibers in particular, the scientists are researching and comparing the size of the MF boutons as well as the connections. Is there a group of MFs that have 2 boutons connect to the same pairs of Pyr cells? If so, why is that? Are certain Pyr cells having more MFs connecting to them? The scientists are running connectivity matrixes, etc. as part of their research.

PS. As far as I know all the cell types are known in CA3. I think some exceptions might be the inhibitory cell types…

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Nice, thank you for the reply! Speaking of post synaptic connections…when do we get to play with that post synaptic tab in the gsheet? Asking for a friend lolxD

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@Nseraf
Does “hippocampus” really mean “seahorse” in Greek? And is it pronounced the same way as in English? :smiley:

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Yes!
Ιππόκαμπος: ϊππος ancient Greek for Άλογο aka horse. and κάμπος which -also in ancient Greek- means sea monster or sea animal therefore seahorse in modern Greek we still call it that or Άλογακι της Θάλλασας (Horse of the sea).

As to the pronunciation the accent goes where you see the ΄ above a letter/vowel, and it sounds more like Epokampos rather than hippocampus. :slight_smile:

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Cool! Thanks!

In Polish it’s “konik morski” or “little sea horse” :smiley:

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interestingly we call praying mantises “horse of the virgin marry” Αλογάκι της Παναγίας. Do not ask me why I do not know xD. And I hate the things…

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lol yes its the same for modern Greek version of horse of the sea, its more little horse of the sea but ‘little horse’ becomes 1 word, you know like Nikitas can become Nik or Richard can become Rick or Di…you get the idea out of affection), but its not easy to translate as one word in English lol

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I got it. Same in Polish: horse - koń, little horse - konik (or mały koń, if we want more literal translation). I really miss diminutives in English.

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ikr? lol it gets funnier when diminutives come in 'neutral" ie: cat w/o saying male or female cat, just cat, or baby, male and female lol Aaaand now we’re veering off subject. lol

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